Page 17 - 4_TOC special applications
P. 17
SCA-130-407
Foods are generally not considered to be Final-rinse method: In indirect sampling, a
pure substances, as they contain different final rinse with water is carried out after
organic compounds such as carbohydrates, cleaning. This final rinse water is subse-
fats or proteins. Next to the actual product, quently analyzed. The advantage of the
TOC analysis also detects surfactants that final-rinse method clearly is its speed. All
are used for cleaning. that is needed is bottling and analyzing of
the final rinse water.
In practice, a combination of the swab
method and the final-rinse method is gen-
erally used in cleaning validation. This way,
the entire production system as well as
specific critical areas can be examined.
■ Measurement parameters
Measurement type: NPOC
Addition of acid: 1.5%
Sparge time: 5 minutes
■ Sampling Injection volume.: 50 μL
40
Swab method: Direct sampling is carried out
using the swab test. This involves careful 30
wiping of a defined, accurately measured Signal[mV] 20
surface of the production equipment using a 10
swab. The swab is subsequently extracted in 0
a vial containing ultrapure water. The extract -4 0 5 10
is analyzed for its TOC content. In swab Zeit[min]
analysis, the results are usually expressed in Figure: 3 Injections of the final rinse.
2
mg/cm .
The advantage of the swab method is the The NPOC content of the final rinse is 3
very accurate examination of small and par- mg/L. The TOC limit value for cleaning valida-
ticularly critical areas. tion of the production system is 10 mg/L. The
cleaning efficiency was therefore verified.
However, TOC determination via the swab
method is more time-consuming and is only
used for smaller parts of the entire production ■ Recommended analyzer / configuration
system. TOC-L CXH or TOC-V WP
ASI-L / ASI-V
