Page 17 - Shimadzu Journal vol.2 Issue4

Topics 117

Dr. Michael MacCoss, Professor at the University of Washington,
rapid time scale has been impressive,” said Brendan MacLean,
methods and results across instrument platforms. By including
Their effort to complete the integration with Skyline in such a
“Shimadzu has been an excellent collaborator to work with.
proteomics. It is important to foster a broad sharing of both
Shimadzu’s high-sensitivity triple quadrupole platforms into
School of Medicine, Department of Genome Sciences, said:
Skyline, it enables the proteomics community to work with
Washington, School of Medicine, Department of Genome
“Skyline is a community effort in the field of quantitative
Software Project Manager for Skyline at the University of
Shimadzu seeks to redefine quantitative proteomics by enabling powerful
Skyline software support on its ultra-fast mass spectrometry platforms

Collaboration between Shimadzu Corporation and
far-reaching technologies.” “We are now excited to redefine the quantitative proteomics market in collaboration with the MacCoss Lab and their outstanding software. MacCoss Lab has brought together Shimadzu’s class-leading mass spectrometry platforms and Skyline software to help enhance quantitative proteomics workflows. We will continue our effort to develop and provide the best solutions to our customers,” said Kozo Miseki, Corporate Officer, Deputy General Manager of Analytical & Measuring Instruments Division, Shimadzu Corporation.
the MacCoss Lab of Biological Mass Spectrometry,

Sciences. Skyline is an open source software project, started in 2008 by the MacCoss lab at the University of Washington. It is now the leading software application for building Selected Reaction Monitoring (SRM)/Multiple Reaction Monitoring (MRM), Parallel Reaction Monitoring (PRM - Targeted MS/MS and DIA/SWATH) and targeted DDA with MS1 quantitative methods and analyzing the resulting

University of Washington Shimadzu Corporation released the new mutual support between the Skyline quantitative proteomics software and Shimadzu's high-sensitivity triple quadrupole LC/MS/MS As mass spectrometry-based proteomics technologies continue to play an ever-increasing role in biomarker discovery, validation and translation for biological and clinical applications, advances in throughput and multiplexing are necessary to improve quantitation of biomarkers in this emerging field referred to as quantitative Clinical Chemistry Proteomics (qCCP). To bring qCCP applications closer to clinical laboratories, Shimadzu has integrated its ultra-fast LC/MS/MS platforms with the powerful, freely

platform. standardize to. About Skyline

conditions; samples are often insufficient or contaminated, metabolisms
techniques, for the advancement in the fields of forensic toxicology and
and decomposition obscure the identity of the parent drug. Thus, we
should make full efforts to learn the latest studies and share useful
Hitoshi TSUCHIHASHI, Division of Preventive and Social Medicine, Department of Legal Medicine, Osaka Medical College, JAPAN

Recent Tendency in Japan and Analytical Strategies

criminal investigations. 1) Zaitsu, K.; Katagi, M.; Kamata, H.; Kamata, T.; Shima, N.; Miki, A.; Tsuchihashi, H. and Mori, Y.:Determination of the metabolites of the new designer drugs bk-MBDB and bk-MDEA in human urine. Forensic Sci. Int., 188, 131–139 (2009). 2) Katagi, M.; Zaitsu, K.; Shima, N.; Kamata, T.; Kamata, H.; Nakanishi, K.; Nishioka, H.; Miki, A. and Tsuchihashi, H.: Metabolism and Forensic Toxicological Analyses of the Extensively Abused Designer Drug Methylone. TIAFT Bull., 40, 30-35 (2010). 3) Shima, N.; Katagi, M.; Kamata, H.; Matsuta,S.; Nakanishi, K.; Zaitsu, K.; Kamata, T.; Nishioka, H.; Miki, A.; Tatsuno, M.; Sato, T.; Tsuchihashi, H. and Suzuki, K. : U

global w430×h280 Drugs and Poisons Involved in Criminal Cases: Increasing numbers of criminal cases involving drugs and poisons have been reported in Japan. Sleeping pills are frequently used in atrocious crimes, such as murder and sexual assault. There have also been many cases where foreign substances, such as agrochemicals or poisons, are mixed into food or drinks. Moreover, the wide spread of newly-encountered drugs, in addition to classical illicit drugs such as methamphetamine, has become a serious social problem. Thus, analyses of drugs and poisons in various specimens, as well as determination of drugs and metabolites in biological specimens are becoming increasingly important in criminal investigation

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