Page 15 - Shimadzu Journal vol.2 Issue4
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                                         Characterization of metabolites in microsomal metabolism of aconitine by high-performance
                                              Aconitine (AC) is a bioactive alkaloid from plants of the genus Aconitum, some of which have been widely used as medicinal herbs
                                                for thousands of years. AC is also well known for its high toxicity, which induces severe arrhythmias leading to death. The study of
                                                 metabolic pathways is very important for efficacy of therapy and evaluation of toxicity for those with narrow therapy windows.




                                           liquid chromatography/quadrupole ion trap/time-of-fight mass spectrometry


                                                               Simultaneous Screening and Quantitation of Amphetamines in Urine
                                                   The aim of our work was to obtain the metabolic pathways of AC by the human liver microsomes.

















                                                                 by On-line SPE-LC/MS Method The new SAMHSA guidelines, implemented in Oct 2010, allow the use of LC/MS and LC/MS/MS for the screening, confirmation  and quantitation of illicit drugs, including amphetamines. The objective of this study was to develop an on-line SPE-LC/MS method  for analysis of five amphetamines in urine without sample pre-treatment except dilution with water. Simultaneous analysis for forensic drugs in human blood and urine using ultra-high speed LC-MS/MS The simultaneous analysis of drugs of abuse in clinical and forensic laboratories requires highly specific system. Conventional  procedures to analyze drugs in complex matrices like whole blood involve ted






                                     Food Safety           Forensics            Forensics             Forensics           Forensics           Forensics




                                     Poster 6              Poster 7             Poster 8              Poster 9            Poster 10           Poster 11




























                                                                         sensitive method to assay mycotoxins in complex matrices is mandatory. In this study, we tested three kinds of samples: baby
                                                                      Mycotoxins are toxic metabolites produced by fungal molds on food crops. Depending on the potency of the mycotoxin and
                                                                Highly sensitive and rapid simultaneous method for 45 mycotoxins in baby food samples
                                                                        the use of the food, the maximum allowed level is defined by legislation. Baby food is particularly critical. Therefore, a



                                                                           milk powder, milk thickening cereals (flour, rice and tapioca) and a vegetable puree mixed with cereals.



                                            The following posters were presented at recent international conferences in 2014,
                                               such as ASMS 2014, ISCC 2014 and TIAFT 2014. Click the title URLs to download








                                      Posters from Recent Conferences
                                                                   by HPLC-MS/MS using fast polarity switching
                                                                                       of Amphetamines in Urine by LC/MS/MS Development and Validation of Direct Analysis Method for Screening and Quantitation  The new guidelines of SAMHSA under U.S. Department of Health and Human Services, effective as of Oct. 2010, allowed the  use of LC/MS/MS for screening, confirmation and quantitation of illicit drugs, including amphetamines. The objective of this  study was to develop a fast LC/MS/MS method for direct analysis of amphetamines in urine without sample pre-treatment  Quantitative analysis of anabolic steroids in control samples from food-producing animals  using a column-switching LC-HESI-MS/MS assay The use of natural and synthetic horm











                                                             Food Safety         Forensics      (except dilution with water) on UFMS.  Food  Forensics  samples for drug residues  Pharmaceutical  formulation using LC/MS/MS  DRN-IB and BHBNB.


           global w430×h280                      the posters of interest.  Poster 1  Poster 2         Poster 3            Poster 4                Poster 5













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