Page 16 - Shimadzu Journal vol.2 Issue4
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Topics                                                                                                                                                 117




                                                                     Dr. Michael MacCoss, Professor at the University of Washington,
                                                           rapid time scale has been impressive,” said Brendan MacLean,
                                                                              methods and results across instrument platforms. By including
                                                         Their effort to complete the integration with Skyline in such a
                                                       “Shimadzu has been an excellent collaborator to work with.
                                                                           proteomics. It is important to foster a broad sharing of both
                                                                                Shimadzu’s high-sensitivity triple quadrupole platforms into
                                                                       School of Medicine, Department of Genome Sciences, said:
                                                                                  Skyline, it enables the proteomics community to work with
                                                                Washington, School of Medicine, Department of Genome
                                                                         “Skyline is a community effort in the field of quantitative
                                                             Software Project Manager for Skyline at the University of
                                               Shimadzu seeks to redefine quantitative proteomics by enabling powerful
                                                   Skyline software support on its ultra-fast mass spectrometry platforms



                              Collaboration between Shimadzu Corporation and
                                                                                    far-reaching technologies.” “We are now excited to redefine the quantitative proteomics  market in collaboration with the MacCoss Lab and their  outstanding software. MacCoss Lab has brought together  Shimadzu’s class-leading mass spectrometry platforms and  Skyline software to help enhance quantitative proteomics  workflows. We will continue our effort to develop and provide  the best solutions to our customers,” said Kozo Miseki,  Corporate Officer, Deputy General Manager of Analytical &  Measuring Instruments Division, Shimadzu Corporation.
                                 the MacCoss Lab of Biological Mass Spectrometry,




                                                                  Sciences.                                          Skyline is an open source software project, started in 2008 by the MacCoss lab at the University of Washington.  It is now the leading  software application for building Selected Reaction Monitoring (SRM)/Multiple Reaction Monitoring (MRM), Parallel Reaction  Monitoring (PRM - Targeted MS/MS and DIA/SWATH) and targeted DDA with MS1 quantitative methods and analyzing the resulting










                                    University of Washington   Shimadzu Corporation released the new mutual support  between the Skyline quantitative proteomics software and  Shimadzu's high-sensitivity triple quadrupole LC/MS/MS  As mass spectrometry-based proteomics technologies continue  to play an ever-increasing role in biomarker discovery, validation  and translation for biological and clinical applications, advances  in throughput and multiplexing are necessary to improve  quantitation of biomarkers in this emerging field referred to as  quantitative Clinical Chemistry Proteomics (qCCP). To bring  qCCP applications closer to clinical laboratories, Shimadzu has  integrated its ultra-fast LC/MS/MS platforms with the powerful,  freely


















                                                             platform.                              standardize to.  About Skyline


















                                              conditions; samples are often insufficient or contaminated, metabolisms
                                                     techniques, for the advancement in the fields of forensic toxicology and
                                                 and decomposition obscure the identity of the parent drug.  Thus, we
                                                   should make full efforts to learn the latest studies and share useful
                                          Hitoshi TSUCHIHASHI, Division of Preventive and Social Medicine, Department of Legal Medicine, Osaka Medical College, JAPAN










                                   Recent Tendency in Japan and Analytical Strategies


                                                       criminal investigations. 1) Zaitsu, K.; Katagi, M.; Kamata, H.; Kamata, T.; Shima, N.; Miki, A.;  Tsuchihashi, H. and Mori, Y.:Determination of the metabolites of the new  designer drugs bk-MBDB and bk-MDEA in human urine. Forensic Sci. Int.,   188, 131–139 (2009). 2) Katagi, M.; Zaitsu, K.; Shima, N.; Kamata, T.; Kamata, H.; Nakanishi, K.;  Nishioka, H.; Miki, A. and Tsuchihashi, H.: Metabolism and Forensic  Toxicological Analyses of the Extensively Abused Designer Drug Methylone.  TIAFT Bull., 40, 30-35 (2010). 3) Shima, N.; Katagi, M.; Kamata, H.; Matsuta,S.; Nakanishi, K.; Zaitsu, K.;  Kamata, T.;  Nishioka, H.; Miki, A.; Tatsuno, M.; Sato, T.; Tsuchihashi, H.  and Suzuki, K.  : U


























           global w430×h280     Drugs and Poisons Involved in Criminal Cases:   Increasing numbers of criminal cases involving drugs and poisons have  been reported in Japan.  Sleeping pills are frequently used in atrocious  crimes, such as murder and sexual assault.  There have also been many  cases where foreign substances, such as agrochemicals or poisons, are  mixed into food or drinks.  Moreover, the wide spread of  newly-encountered drugs, in addition to classical illicit drugs such as  methamphetamine, has become a serious social problem. Thus, analyses of  drugs and poisons in various specimens, as well as determination of drugs  and metabolites in biological specimens are becoming increasingly  important in criminal investigation











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