Page 6 - Shimadzu Nexera MX

A3 w420×h297

Simple Workflow Supports High Throughput LabSolutions Connect make full use of the high-throughput performance of Nexera MX. It seamlessly supports the series of operations
from MRM optimization to batch queue execution, improving process efficiency.

Cytochrome P450 (CYP) cocktail inhibition assay monitoring of multiple substrates is one of the major tests during early drug
discovery. This section introduces the sequence of procedures for performing MRM optimization in advance for target compounds Supporting MRM Optimization
known to be substrates of CYP molecule species, creating an analysis method from the MRM transition information registered in the
The easily configured automatic MRM optimization function and the
database, and performing real-time batch and data analysis.
data browser function for checking optimization results reduce the
work involved in the optimization process for multiple samples.

LabSolutions Connect

1 Extract MRM transitions 2 Create method and batch files
● Open a compound database file. ● Select the LC method used for analysis.
● Select a compound list of drugs for analysis. ● Enter the settings required for real-time batch
(vial positions, settings for calibration curves, etc.).

Creating Method and Batch Files, Executing Analysis, and Managing the Batch Queue

With LabSolutions Connect, the required information from MRM optimization results registered in the database can be accessed by
loading in a text file, and then a method file used for analysis can be easily created. In addition, the settings for the batch file
saved in a text file can be loaded, speeding up the process of batch file creation. The intuitive graphical user interface reduces the
burden on the user when configuring a real-time batch analysis.

3 Execute analysis and manage batch queue
● Start real-time batch.

LabSolutions Insight

Data Analysis and Report Creation
● Check the concentration values for substrates while displaying in parallel the substrates for analysis and the configured IS peaks.

Processing Large Amounts of Data by LabSolutions Insight

Large-volume data sets obtained after data acquisition are analyzed
using LabSolutions Insight.
With LabSolutions Insight, the MRM chromatograms to be reviewed
can be displayed in a stack.
In addition, peak identification can be collectively processed via
manual operation for peaks displayed. This reduces the time required
for data processing, enabling more efficient data review.

Even when multiple drugs are grouped for cassette administration, it is easy to extract only the required MRM transition
information from the registered database, and then create an analysis method. LabSolutions Connect is a very powerful tool for
automating and heightening the efficiency of the entire sequence, from creating method files to performing analysis, and even
analyzing data.

Nexera MX
6 Ultra-High Speed LCMS System for Multiplex Analysis 7