Page 5 - Shimadzu Nexera MX

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Original hardware control technology

cuts analysis time in half!

Conventional analysis requires performing various processes such Therefore, demands have increased for LCMS systems that Ultra-fast and Ultra-low Carryover Autosampler SIL-40 Series
as column washing, equilibration at initial mobile phase shorten the time spent for processes other than data acquisition
concentrations, and the next sample injection by the in order to improve analytical throughput. High Capacity PLATE CHANGER
autosampler during the analysis.

In an analysis of four biomarker compounds for the
Analysis time
four major molecular species in the Cytochrome Analysis Cycle Time Less Than 10 Seconds
Time period to Time period to perform P450 family, the Nexera MX completed the analysis The SIL-40 autosampler can process the entire injection
acquire data other processes such as in only 38 seconds whereas conventional HPLC
equilibration of columns required one minute, 22 seconds. cycle time in as little as seven seconds, twice as fast as the
previous model. In addition, continuous analysis can be 6.7 sec
carried out on up to 44 MTPs (using 3 PLATE CHANGERS).
Together these features dramatically increase analysis
throughput.
2 Fold
Nexera MX Throughput
System

0.00 0.25 0.50 0.75 1.00 1.25 min
8 injections can be completed within 1 minute (Caffeine)

Ultra-low Carryover

The Nexera boasts ultra-low carryover, even on a high-sensitivity LC/MS/MS.
38 seconds
This reduces time spent on rinsing, resulting in a shorter overall analysis time.
Conventional
HPLC System 3.0 (x10,000)
2.5
Chlorhexidine 500 ng/µL
2.0
1 min 22 seconds 1.5 Blank
1.0
0.5
Nexera MX Dual Stream Technology (MX-DST) 0.0
0.0 0.5 1.0 min
Drain
The MX-DST incorporates a special flow line
Analysis
Stream 1 Pump Column structure and instrument control system, and
performs overlap control of sample injection by
Autosampler LCMS using two analysis systems (streams) alternately.
Wash / Equilibration As a result, after one system completes data
Stream 2 Pump Column acquisition, the other system starts data 3.0 (x1,000)
acquisition immediately, making it possible to
Drain 2.5
use nearly the whole time of LCMS operation for 2.0
Drain data acquisition.
Wash / Equilibration 1.5 Carry over
Stream 1 Pump Column 1.0 0.00007%
0.5
Autosampler LCMS 0.0
Analysis 0.30 0.6 0.9 min
Stream 2 Pump Column Rinse Conditions: Normal
Drain

Nexera MX
4 Ultra-High Speed LCMS System for Multiplex Analysis 5