Page 5 - Shimadzu Nexera FV
P. 5

System Configuration for Online Dissolution Testing  Two Analysis Modes Promote Faster Dissolution Testing



 With the Nexera FV, the dissolution tester and the autosampler are connected online, so everything is automated from sampling   Direct Injection Analysis Mode: Exclusively with the Nexera System
 to dilution to data acquisition and analysis. As a result, there is less test-related work for the operator, and a subsequent increase
 in processing throughput.   In this mode, the dissolution medium delivered from the dissolution tester is directly loaded and analyzed. This is effective if the
 In addition, there is no manual dispensing of samples, ensuring reliable results.  analysis of the number of vessels finishes before the next sampling interval.
               This analysis mode can be selected precisely because the Nexera FV is compatible with UHPLC analysis.
 Nexera FV



 Dissolution tester  Filter station
 Connected online
                    Dissolution
 PC                    Tester







                                                                                        Analyze
                                                                                        Directly










                  Fraction Analysis Mode: For Confirmation of Dissolution Profiles
                  at Short Sampling Intervals
 Flow Vials Provide Automated Dissolution Testing
               This analysis mode is used for tests in which the sampling interval is short. This is suitable when checking the
 A dissolution medium from the dissolution tester flows   Depending on the dissolution tester used, 8 or 12 flow   dissolution profile of instantly soluble samples. The Nexera autosampler's high-speed performance makes this
 directly into flow vials loaded into the autosampler. A   vials can be loaded. Further, since the flow vials are   system compatible with sampling intervals as short as five minutes. In addition, up to 768 samples can be
 bubble suppression design has been adopted for these   purposefully designed not to control the temperature, salt   fractionated, making this mode effective when the dissolution quantity is large and dilution will be required.
 flow vials, enabling high-accuracy sampling of dissolution   precipitation from the dissolution medium is suppressed.
 media.





                    Dissolution
                       Tester





                                             Fractionate                          Analyze















 4                                                                                                                 5
   1   2   3   4   5   6   7   8