Page 4 - Shimadzu Nexera FV
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System Configuration for Online Dissolution Testing                                                                Two Analysis Modes Promote Faster Dissolution Testing



                     With the Nexera FV, the dissolution tester and the autosampler are connected online, so everything is automated from sampling   Direct Injection Analysis Mode: Exclusively with the Nexera System
                     to dilution to data acquisition and analysis. As a result, there is less test-related work for the operator, and a subsequent increase
                     in processing throughput.                                                                                          In this mode, the dissolution medium delivered from the dissolution tester is directly loaded and analyzed. This is effective if the
                     In addition, there is no manual dispensing of samples, ensuring reliable results.                                  analysis of the number of vessels finishes before the next sampling interval.
                                                                                                                                        This analysis mode can be selected precisely because the Nexera FV is compatible with UHPLC analysis.
                                                                           Nexera FV



                                      Dissolution tester    Filter station
                                                          Connected online
                                                                                                                                              Dissolution
                                                                                              PC                                                 Tester







                                                                                                                                                                                                                 Analyze
                                                                                                                                                                                                                 Directly










                                                                                                                                           Fraction Analysis Mode: For Confirmation of Dissolution Profiles
                                                                                                                                           at Short Sampling Intervals
                        Flow Vials Provide Automated Dissolution Testing
                                                                                                                                        This analysis mode is used for tests in which the sampling interval is short. This is suitable when checking the
                     A dissolution medium from the dissolution tester flows   Depending on the dissolution tester used, 8 or 12 flow      dissolution profile of instantly soluble samples. The Nexera autosampler's high-speed performance makes this
                     directly into flow vials loaded into the autosampler. A   vials can be loaded. Further, since the flow vials are     system compatible with sampling intervals as short as five minutes. In addition, up to 768 samples can be
                     bubble suppression design has been adopted for these   purposefully designed not to control the temperature, salt   fractionated, making this mode effective when the dissolution quantity is large and dilution will be required.
                     flow vials, enabling high-accuracy sampling of dissolution   precipitation from the dissolution medium is suppressed.
                     media.





                                                                                                                                              Dissolution
                                                                                                                                                 Tester





                                                                                                                                                                       Fractionate                          Analyze















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