Page 2 - AXIMA Performance

AXIMA Performance™ -

the Next Generation in MALDI CID MS/MS

A high performance MALDI-TOF-TOF Essential features providing
mass spectrometer utilizing state-of-the- confident results
art high-energy MS/MS, delivering
unparalleled flexibility, in a robust and This next generation design MALDI system delivers all of
the features expected of an AXIMA series mass
reliable research grade system.
spectrometer:
• High resolution MS data in reflectron mode for more
accurate and confident analysis
• Uncompromized linear mass range and sensitivity
• Near-axis laser irradiation for enhanced ion
transmission and sensitivity in all modes of operation
• Advanced calibration algorithms with easy-to-use
software providing more accurate data
• Intuitive software incorporating data-dependent
workflows for achieving the maximum result with the
minimum user input, making it ideal for novice and
expert users alike
• Flexibility – this is a true workhorse. Polymers,
oligonucleotides, SNPs, metabolites, carbohydrates and
small molecules amongst others may all be analyzed
and processed.

Advanced MS/MS performance

The monoPULSE™ high performance, revolutionary ion
gate provides outstanding MS/MS precursor ion selection
resolution. When complex mixtures are analyzed, the
high resolution ion gate allows optimal isolation of ions
with similar nominal mass, affording successful
separation of MS/MS fragmentation patterns, producing
more and higher confidence identifications. Resulting
MS/MS spectra are easier to interpret and significant
database search hits are more readily achieved. The
• Highest energy collisions – CID with a laboratory frame high-energy collisions, together with the curved field
collisional energy of 20 keV reflectron (CFR) produce well-balanced, information-rich
• Outstanding sensitivity – uncompromised design, MS/MS data.
to ensure no MS/MS signal is discarded • The unique combination of the advanced curved field
• Low sample consumption – allowing many more reflectron design and the high-energy collision cell
MS/MS experiments to be performed on the same means that all fragment ions formed are detected,
sample spot regardless of where they are formed in the instrument.
Both LID and CID ions are accumulated into a seamless
• Variable repetition rate laser
spectrum providing the best possible MS/MS sensitivity.
• Optimal precursor ion selection resolution using
• The Low Mass Zoom™ (LMZ) feature allows rapid
revolutionary ion gating technology
enhancement of the region of the spectrum
• Manual or fully automated operation allowing the encompassing the immonium ions and isotopically
seamless analysis of as few or as many samples as labelled quantitative diagnostic ions.
required
• Gridless ion path, unique to leading MS/MS systems,
• Fully enabled for protein identification –
designed to avoid unwanted ion scattering and ensure
Intellimarque™ software suite for automated
the highest possible ion transmission.
data-dependent peptide mass fingerprinting and
• High sensitivity allowing multiple MS/MS acquisitions on
MS/MS of peptides with optional incorporated
the same sample spot through low sample consumption.
Mascot® database searching
• LC-MALDI software allowing confident identification of
off-line separated complex mixtures via automated
MS/MS