Page 4 - Clinical-Medical Physical Properties of Biomaterial

Evaluation of Biological Samples Muscles, tendons, and ligaments are directly related to our movements and are worked extremely hard. Sample Upper grip
Tensile Testing of Muscle, Tendon, and Ligament
Evaluation of Biological Samples Medical breakthroughs always start with knowledge about human beings. ligaments, skin, muscle, and arteries), replacement biomaterials, artificial ligaments can be over-tensioned and break. Lower grip Tendon Evaluation of Biological Samples
winding drum
Tendons connect bone to muscle cells, while ligaments connect bone to bone. Both tendons and
Temporary fixing screw
The jig shown in the diagram to the right is used for tensile testing of muscles, tendons, and ligaments.
The method of holding the sample is problematic when testing living cells such as fibriform tissue. An
tissue and artificial bone. This includes characterization testing to understand
Gaining an understanding of the structure and functions of the organs,
Bone
appropriate method for testing a tendon is to grasp the biological sample in the lower grips and to
skeleton, tendons, and blood vessels, as well as their physical strength, is
the mechanical properties of such tissues and materials.
wind the top of the tendon around the upper drum.
indispensable when developing biomaterials.
The testing covers a wide range from simple tensile, compression, and bending tests
The drum has a split construction, and the surfaces that hold the tendon are rubber-coated to prevent
to dynamic tests using fatigue and endurance testers, and complex, multi-axial tests.
Research into new materials and new regenerative medicine has made
the sample from rupturing.
dramatic strides in recent years and remains at the forefront of research
Some examples of mechanical testing and evaluation of biological tissue from
Rubber coating
Shimadzu's extensive track record are introduced below.
around the world. The research covers bone, soft tissue (such as tendons,
The Autograph AG Series Precision Universal Tester combines technologies fostered over Biological tissue samples are gripped by rubber-coated
many years with sophisticated control and measurement performance. In addition, it offers teeth and wound onto the drum. This reduces damage
great operability and convenient support functions. This is a testing system that offers to the sample by the grip. Tensile Testing Jig for Biological Tissue
excellent accuracy and ease-of-operation. Tendon
Evaluation of Biomaterials without a computer. TRAPEZIUM X software was developed to offer even greater Our skeleton forms the framework of our bodies. There are about 200 major bones in the body, Evaluation of Biomaterials
The smart controller permits instant data check and fine adjustment of the test position.
The color TFT touch panel makes operation easier and allows the system to be operated
convenience, enabling more efficient test results evaluation and analysis operations.
Mechanical Evaluation of Bone
The AG Series contributes to customers' testing work from three perspectives:
performance, operation, and support.
which are said to come in five basic shapes. These bones are linked in a specific arrangement to
form the human skeleton. Bones must have adequate strength to support the person's body weight
while walking or jumping but be light enough to allow nimble movement. They can break when
excess force is applied. They also must have a degree of brittleness to absorb shocks.
Numerous tests are performed to understand a bone's mechanical properties, as well as to confirm
the efficacy of osteoporosis medication and to develop artificial. Jigs for the testing and evaluation
Evaluation of Medical Equipment Humans have to think and move around to stay alive. The energy source for these that is used as a matrix in regenerative medicine. It is seeded with autologous cells Compression and Bending Testing Evaluation of Medical Equipment
of bones are introduced below.
Color TFT Touch Panel
Smart Controller
Autograph AG Series, Table-Top Type
TRAPEZIUM X Software for Static Material Testing Machines
Tensile Testing of Artificial Skin and Tubular Tissue Including Blood Vessels
Generally, three-point bending tests are performed on tibias and femurs of rats, dogs, and monkeys,
while compression testing is performed on the lumbar vertebrae. Due to the small size of mouse
for ureteral regeneration.) The Autograph Series Universal Tester features a
movements is provided though the blood vessels. Blood vessel disorders include
samples, three-point bending tests are performed on the tibia.
high-accuracy load cell and high-speed sampling to perform measurements at low
hardening of the arteries (arteriosclerosis), aortic aneurysms and varicose veins that
These tests are performed using a compression/bending test device. A special vice is required to hold
form bulges on blood vessels, and arterial occlusions that block blood flow. In some
cases, artificial blood vessels are transplanted to treat such blood vessel disorders.
The S-S curves below plot the test force (N) along the vertical axis and the sample
cell, and capacity of the vice and jig that must be used.
displacement (= stroke, mm) along the horizontal axis in tensile testing. It is
The measurement of the mechanical properties of blood vessels, including the
The bone mechanical parameters obtained from the S-S curve (stress-strain curve) for bending tests
apparent that the dog ureter achieves higher maximum test force and displace-
carotid artery, jugular vein, aorta, and inferior vena cava, and of tubular tissues such test forces, while capturing the smallest sample deformations. the bone for compression testing. The size of the measured bone sample determines the tester, load Bending punch
2
include the maximum test force (N), maximum elongation (mm), maximum stress (N/mm ), maximum
as ureters and ureter decellularized matrixes is extremely important. (A ureter ment, indicating superior strength and elasticity. Correct selection of the grips and
strain (%), and the energy (N mm). Bone
Evaluation of Pharmaceuticals and Packaging 12 8 6 4 2 Max 12 8 6 4 2 Max Rat bone Standard compression plate Support Evaluation of Pharmaceuticals and Packaging
grip faces is important for soft samples, like biological samples.
decellularized matrix is a ureter with the cell components scientifically eliminated
15
15
14
14
Max
Test force (N) 10
Test force (N) 10
Max
Sample vice
Break
Break
Break
Break
0
9
6
12 15 18 21 24 27 30
0
3
6
9
0
3
12 15 18 21 24 27 30
Break
Break
Stroke (mm)
Stroke (mm)
Tensile Testing of Dog Ureter
Tensile Testing of Artificial Blood Vessels
(Ureter Decellularized Matrixes)
Dog Carotid Artery
Test Force-Displacement Diagram 0 Test Force-Displacement Diagram Pneumatic Flat Grips Tensile Test Evaluation of Compression Tester Three-Point Bending Tester
Physical Property Testing Equipment
for Biomaterials and Medical Applications
4 Solutions for Biomedical Testing 5