Page 3 - Shimadzu MALDI-8020
P. 3
TrueClean™ automated source cleaning 100 80751
To maintain instrument performance over time, the 90
MALDI-8020 features wide-bore ion optics - a feature used 80
on our existing MALDI-TOF products - which minimize the 70
160349
risk of source contamination over time, providing a robust 60
platform. % Intensity 50
To maximize uptime, the system is equipped with TrueClean - 40 46704
an automated, rapid (<10 min) UV laser-based source 30
cleaning which can be used to clean the extraction electrode 20 54239
40812
in-situ without breaking instrument vacuum. 10
0
50000 100000 150000 200000 250000
m/z
Polycarbonate monomer from bisphenol A: Example of higher mass analysis using immunoglobulin A (IgA)
1365.1
1110.9 1619.3 2127.6 O OC = 254.1
1873.5
5
2381.8
127.6
2
2635.9
2381
8
2890.0 3399.2 2127.6 O n 2381.8 Quality as standard
3398.2
1038.7 1443.2 1951.55 2205.7 2713.9 3144.1 2205.7 2309.6 As mass spectrometry moves into clinical laboratories, the
2459.8 2970.1
1697.3
2205.7
205.7
5
100 1111.0 24545 100 90 MALDI-8020 is the perfect choice for researchers developing
90 1619.5 80
†
80 70 2127.9 MALDI-based diagnostic methods . The system is designed
60 50 40 254.1 2382.0
2127.9
% Intensity 60 50 1873.8 2 2636.2 3145.4 30 20 10 0 2100 2150 2200 2250 2300 2350 2400 and manufactured to ISO 9001:2015 and ISO 13485:2016
70
127.9
3653.6
3144.4
2382
1547.4
8
30 40 1039.0 1365.4 8 2382.0 2890.3 3399.5 m/z quality management standards and is CE compliant.
20 1294.4 2715.1 3223.4
2055.72460.1 2464
10 1801.6 55.75 Through the selection of components demonstrating
0
25
1000 1500 2500 3000 3500 4000 4500 5000 5500 6000
m/z improved longevity and performance, and by reducing the
number of component parts, our engineers have created a
Polymer analysis: polycarbonate from a CD (green spectrum) and
polycarbonate standard (orange spectrum). reliable and robust platform capable of delivering
Inset: expanded view of the highlighted region. outstanding performance in a small footprint.
The MALDI systems are maintained by trained service support
engineers who form part of the Shimadzu global distribution
505.2
100
and support network. Routine maintenance is simplified
90 505.2 HN NH
100 HN NH HN NH
80 NH HN thanks to the instrument design, providing our engineers
90
HN NH
70 80 70 with easy access to commonly serviced parts.
% Intensity 60 50 507.3 % Intensity 60 50 40 507.3 Cl Cl † For Research Use Only. Not for use in diagnostic procedures.
40
20 30 Chlorhexidine
30
10
20 0
490 492 494 496 498 500 502 504 506 508 510 512 514 516 518 520 522 524
m/z
10
0
350 400 450 500 550 600 650 700 750 800 850 900 950 1000
m/z
Analysis of chlorhexidine gluconate in mouthwash solution. Sample
was prepared with MALDI matrix without any clean-up or dilution.
Inset: expanded view showing peak at 505.2 m/z.
Facilitates 21 CFR Part 11 compliance
Operating under the control of MALDI Solutions™ software,
the software features a centralized, secure Microsoft ® SQL
database which can be used to store everything from sample
lists and acquisition Parameter Sets to acquired MALDI data.
The system is managed by an Administrator and customizable
user profiles provide control over access to the database and
operation of the instrument. Along with a full audit trail, the
software provides the tools to help achieve 21 CFR part 11
regulatory compliance.
MALDI-8020