Page 3 - AXIMA Confidence

AXIMA Confidence™ - Software Solutions

Intuitive software incorporating Synthetic polymers
data-dependent workflows for achieving
maximum results with minimum user Polymers and copolymers can be characterized using our
unique polymer software, Polymer Analysis™, providing
input, making the system ideal for
useful structural information and statistics in a text report
novice and expert users alike. format.
The AXIMA Confidence is controlled by the Launchpad™
Oligonucleotides
suite of software, common to all AXIMA mass
spectrometers, permitting manual or fully automated
Oligo Analysis™ offers fully automated QC analysis of
operation facilitating the seamless analysis of as few or
large numbers of oligonucleotides or peptides, complete
as many samples as required. Intelligent optimization of with a report indicating the presence or absence of the
acquisition conditions may be employed allowing target compound, an estimate of the purity and
auto-tuning for specific samples. occurrence of known contaminants, adducts or
Ideally suited for life science and analytical environments truncated/expanded analogues.
alike, the system offers software packages specifically
created for: Biomarker discovery
• Proteomics experiments
This exciting area encompassing clinical sample screening
• LC-MALDI and profiling is comprehensively addressed using
• Polymer analysis automated acquisition methods and refined data
• Biomarker discovery processing.
• Oligonucleotide/primer analysis Data can be easily exported to third party software
packages to allow comparative experiments using a
Application-centric data processing software packages
number of standard data formats including ASCII, mzXML
are available to provide solutions to many commonly
and mzData.
asked questions.
System support
Intellimarque™ for automated
protein identification All AXIMA systems can be fully supported throughout
their lifetime using sophisticated web-based service
Designed with the flexibility to adapt to user workflows: diagnostics and realtime remote monitoring. Highly
from a handful of samples to high-throughput fully trained specialist local service support engineers are
automated data generation, data-dependent peptide available to install and maintain AXIMA mass
mass fingerprinting (PMF) and MS/MS for protein spectrometers. A wide range of service contracts is
identification are integrated into easy-to-use intuitive available, catering for all budgets and requirements,
software. The flexibility of the software means it can also including IQ/OQ environments.
be applied to other applications requiring automated
Full training courses are offered by MALDI experts at our
acquisitions other than just protein identification. regional corporate training centers or at the customer
• Peptide mass fingerprints are acquired and subjected site and may be tailored for specific requirements and
to an optional integrated Mascot® database search. applications.
• User-definable limits for acceptance of PMF-based
protein identification.
• Data-dependent MS/MS: using the results of the PMF
% Int. 1881.87
search, MS/MS may be performed on ions that were 100
90
matched to the top ranked protein hit (confirmation
80
MS/MS), in addition to those that were not 70
(investigation MS/MS). 60
50
• Batch searching of these MS/MS spectra is then 40 1639.91
performed automatically to provide additional and 30 1439.77 1479.80 2116.82
20 1017.57 1170.62 1779.77 2525.10
higher confidence protein identifications. 10 1249.58 1305.68 1401.62 1657.72 1732.61 1837.89 1908.88 2020.93 2072.82 2363.85 2459.14 2615.09
• Data may be reprocessed and resubmitted for database 0 1000 1200 1400 1600 1800 2000 2200 2400 2600 2800
m/z
searching at a later time to provide additional
information. Bovine serum albumin peptide mass fingerprint

AXIMA Confidence
3