Page 2 - AXIMA Confidence
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AXIMA Confidence™ - Sensitivity and Flexibility





                  The AXIMA Confidence is designed with         Positive and negative ion modes are included as standard
                  the general analytical and life science       allowing greater flexibility and extending the compound
                                                                categories that may be analyzed. The system also
                  laboratory in mind. Incorporating a
                                                                incorporates a patented beam blanker to optionally remove
                  variable repetition rate 50Hz N laser, the
                                                  2             unwanted low mass ions and prevent detector saturation.
                  system provides rapid, high quality MALDI
                                                                Excellent sensitivity is achieved using near-normal
                  mass spectra and an array of software         (on-axis) laser irradiation and advanced ion optics for
                  tools for data processing and reporting.      enhanced ion transmission. Pulsed extraction of ions from
                                                                the MALDI source, in combination with the unique
                  Linear mode allows the interrogation of high molecular
                                                                reflectron design, improves resolution and enhanced
                  weight samples, whilst reflectron mode, incorporating
                                                                calibration algorithms with easy-to-use software facilitate
                  the patented curved field reflectron (CFR), provides the
                                                                the generation of more accurate data.
                  high resolution and mass accuracy necessary for
                                                                MS/MS may be easily performed using a seamless
                  successful proteomics and life science experiments.
                                                                approach – ions of interest can be isolated using a
                                                                precursor ion selection device, incorporated as standard,
                                                                and data-rich fragment ion spectra quickly and simply
                                                                acquired. The curved field reflectron design augments the
                                                                low mass fragment region providing useful additional
                                                                information.
                                                                Unparalleled flexibility is achieved by a variety of sample
                                                                target formats including standard microtitre plate-format
                                                                96 or 384 well targets. FlexiMass™ microscope slide-
                                                                format targets (plain or 48 well targets) and a wide
                                                                variety of adaptors for unconventional sample layouts are
                                                                also available. The standard sample target formats are
                                                                fully compatible with common laboratory robots.



                                                                 % Int.
                                                                 100
                                                                 90
                                                                 80
                                                                 70
                                                                 60
                                                                 50
                                                                 40
                                                                 30
                                                                 20
                                                                 10
                                                                  0
                                                                      3630  3635  3640  3645  3650 3655  3660  3665  3670  3675  3680  3685  3690  3695
                                                                                      m/z
                                                                ACTH fragment 7-38 showing >15,000 resolution FWHM

                                                                 % Int.
                                                                 100
                                                                 90
                                                                 80
                                                                 70
                                                                 60
                                                                 50
                                                                 40
                                                                 30
                                                                 20
                                                                 10
                                                                  0
                                                                        55000  60000  65000  70000  75000  80000
                                                                                      m/z
                                                                Bovine serum albumin in linear mode











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