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Pharmaceutical and Life Science Environment click here.

Application News No.01-00454
This is an examples of the analysis of foreign matter adhering to the surface of a pharmaceutical tablet. By being taken to a Shown here is an analysis of microplastics collected on polytetrafluoroethylene (PTFE) filter paper. Micro-transmission
diamond cell and rolled, transmission measurement can be performed on various shaped samples. mapping analysis was performed to determine the material of the microplastics using Shimadzu's original UV-damaged
plastics library. The results showed that the microplastics were polyethylene (PE) and polypropylene (PP). The absorption
around 1,200 cm is due to PTFE, the material used for filter paper.
-1
0.3
0.2 Infrared spectrum (a) Infrared spectrum (b)
Abs PE irradiated with ultraviolet light for 550 hours PP irradiated with ultraviolet light for 125 hours
0.1 PTFE PTFE
0.0
4000 3600 3200 2800 2400 2000 1800 1600 1400 1200 1000 800 cm -1
Observation image of the Observation image of the
tablet surface approximately foreign matter on the Spectrum of foreign matter collected in the diamond cell.
8 mm in diameter with the diamond cell by 15× Identified as Carbonate
wide view camera (2× zoom) Cassegrain objective mirror. Abs Abs

Material

Infrared spectra (a) and (b) extracted from mapping analysis results, and search results
This is an analysis example of multilayer film used in potato
chip packaging. Sections of the film were cut with a
microtome and measured by the transmission method. In addition, we performed mapping analysis of microplastics on filter paper. For the mapping data, we created chemical
We also measured the thickness of each layer using the images based on the corrected height of the CH rolling vibration mode of PE (718 cm ) and the CH symmetric deflection
-1
length measurement function. From the inside touching mode of PP (1,373 cm ). 2 3
-1
the chips, each layer was found to be 27 m polypropylene
(PP), 9 m PP + polyethylene (PE), 11 m polyethylene
terephthalate (PET), and 42 m PE.

No. Length(µm)

1 27
2 9
3 11
4 42
Chemical image of microplastics (PE) on filter paper Chemical image of microplastics (PP) on filter paper
Photographs and length measurement results of multilayer film
cross sections (inside on left side of screen)
Microplastics collected on PTFE filter paper were mostly
PP, and it was visually confirmed that PE was present in
some of them. Finally, using the microplastic images
measured in this study, we measured the length of several
microplastics collected on PTFE filter paper. We found
that the filter paper was dotted with multiple plastics of
about 20 ~ 40 microns in size.
Transmission spectra and chemical image of each layer of multilayer film
(First, second, third and fourth layers from the top)

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