Equipped with a heated ESI probe, the LCMS-8045 has the highest sensitivity in its class. The heated ESI probe, high-temperature heating block, desolvation line (DL) and drying gas, all act to promote desolvation and prevent contamination due to the penetration of liquid droplets into the MS unit. This improves the robustness, so reliable and high-accuracy data can be obtained over the long term. The LCMS-8045 also achieves the world’s fastest scan speed (30,000 u/sec) and polarity switching speed (5 msec). These enable ultra-high-speed, high-sensitivity analysis. The excellent cost performance of this system is demonstrated in food safety, environmental analysis, and other quantitative analyses, it can be upgraded to the LCMS-8060
LCMS-8045 Features
Accomplishes Both High Sensitivity and Ultra-High-Speed Detection
Equipped with a heated ESI probe, the LCMS-8045 has the highest* sensitivity in its class. The instrument is capable of providing accurate and stable data over long periods of time. The inclusion of Shimadzu’s ultra-high-speed* high-voltage power supply enables the world’s fastest scan speed (30,000 u/s) and polarity switching time (5 ms). High-speed acquisition benefits the laboratory by reducing run times for increased throughput, and also shortens method development time. * As of August 2016, according to a Shimadzu survey
Superior Robustness Assures That High Sensitivity Is Maintained Over the Long Term
The LCMS-8045 was designed to be robust. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity and minimize contamination. This means long periods of continuous operation in the laboratory with reliable data collection, even with complex biological fluids or food samples.
LabSolutions LCMS Software and Wide-Ranging Method Packages
LabSolutions LCMS features an intuitive user interface, and offers the latest features designed to enhance laboratory productivity and streamline workflows. Numerous pre-configured MRM method packages are available. Predetermined LC separation conditions and MRM parameters allow analysis to be started without long hours of method development, enhancing the efficiency of your laboratory.
Consistent High-Sensitivity Performance
Robust Ion Source and Sample Introduction System
Shimadzu’s MS interface includes a high-sensitivity heated ESI source, heated capillary sample introduction, and proprietary ion transfer optics. These design features combine to produce robust MS performance. 12,000 plasma samples were injected over 25 days (over 480 samples per day). Picogram levels of alprazolam were analyzed with an RSD of 3.42%.
Instrument Detection Limits: IDL
IDL is one measure of sensitivity for analytical instrumentation. The chromatograms below show the IDL for Reserpine and Chloramphenicol, obtained using ESI+ and ESI-, respectively. The IDL for Reserpine is 2.03 femtograms and 2.09 femtograms for Chloramphenicol.
Newly Designed Ionization Unit
Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.
Easy System Maintenance Reduces Downtime
As with Shimadzu’s other triple quad systems, maintaining the LCMS-8045 is simple. Replacing the desolvation line (DL) and ESI capillary is quick and easy.
Additionally, the design allows users to replace the DL without breaking vacuum, providing greater uptime and usability.
